Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor’s Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissue including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.Supplementing with SAMe
The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.SAMe and Joint Function
SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort. SAMe and Neural Health
SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.

Product Features

• Doctor’s Best SAMe Double Strength is proven to enhance mood and promote cognitive health
• SAMe is essential for the healthy metabolism of the major brain transmitters dopamine, serotonin and norepinephrine
• SAMe has been proven to promote joint comfort and mobility and supports liver health and detoxification
• SAMe’s effectiveness has been proven with 18 controlled human trials published over 40 years
• Pharmaceutical grade, Non-GMO, Gluten Free, Vegan